Triggers for BD include bacterial infections (such as Streptococcus sanguis, Helicobacter pylori, and Mycoplasma), viral infections (such as herpes simplex virus type 1, Epstein-Barr virus, hepatitis, and cytomegalovirus), and abnormal autoantigens (such as 60 kDa and 70 kDa heat-shock proteins, S-antigen, interphotoreceptor retinoid-binding protein, α-tropomyosin, and αβ-crystallin)4,16. This evidence concerns the gene RBP3 and Behcet disease.