MMP-2-sheddable PGDA7 and the MMP-2-insensitive PDA7 analogue NPs were administered via intravenous (i.v.)injection at an identical ARV771 dose of 10 mg/kg and PPa dose of 5.0 mg/kg when the tumour volume reached 200 mm3. The gene discussed is MMP2; the disease is neoplasm.