The combination of Laser + PGDA7 NPs activated the caspase-3 protein in MDA-MB-231 tumour cells more efficiently than PDT (Laser + PGDA) or BRD4 degradation with PGDA7 alone (Fig. 6e), implying the improved apoptosis induction performance of PDT combined with BRD4 degradation in vitro. This evidence concerns the gene CASP3 and neoplasm.