The introduction of an interaction term between genotype and disease enabled us to refine our list of possible candidates for further study; one candidate is GSDMD (gasdermin) in the RPE1, which is a potential target for inflammatory conditions109, and gasdermin D is elevated in eyes from geographic atrophy patients where it plays a key role in the NLRP3 inflammasome activation and subsequent RPE death110. This evidence concerns the gene GSDMA and atrophic macular degeneration.