Plasma testosterone and LH/FSH ratio increased while 17-β estradiol and SHBG decreased significantly (p<0.05) in animals with PCOS compared to the control animals, which were significantly reduced and increased (p<0.05) respectively in PCOS+NaAc animals compared to the untreated PCOS animals (Table 1). The gene discussed is BRD2; the disease is polycystic ovary syndrome.