Administration of acetate in the present study also decreased hyperlipidemia, ovarian lipid accumulation, lipid peroxidation, hyperinsulinemia, glucose intolerance, insulin insensitivity, body weight gain, ovarian weight, histomorphological disruptions, plasma testosterone and LH/FSH ratio while 17-β estradiol and SHBG levels were increased in experimentally induced PCOS. Here, PLOD1 is linked to hyperinsulinism.