Our results showed that there were very few COX2+ cells at cartilage in mice fed HFD for shorter periods (0.5, 1, 3, and 4 months) relative to mice fed CHD, whereas there was a much higher number of COX2+ cell number on bone surface (osteoblasts) and in mineralized bone (osteocytes) at these time points (Figure 8A, C and D). Here, PTGS2 is linked to coronary artery disorder.