To determine whether cellular senescence plays a role in osteoarthritis development, we generated conditional Tnfrsf11aCre/+; Cdkn2aflox/flox mice, in which the senescence gene Cdkn2a is deleted in RANK+ osteoclast lineage cells (Maeda et al., 2012; Zou et al., 2016). Here, CDKN2A is linked to osteoarthritis.