Of note, the μCT measurements (Figure 5A-D) and the histological parameters (Figure 5E-H) were not significantly different in the p16cKO mice compared with the WT mice fed a normal CHD, suggesting that subchondral bone remodeling, as well as the activity of osteoclast and osteoblast lineage were not affected by Cdkn2a deletion in osteoclast lineage cells at baseline. The gene discussed is CDKN2A; the disease is coronary artery disorder.