Thus, the field of BET inhibitors will continue to evolve; strong mechanism-based translational studies that identify predictive biomarkers for improved response (such as Y537S mutation status) and rational combination treatments (such as CDK4/6 inhibitors) that synergize with BET inhibition and increase response rates will determine the clinical success of this class of drugs for treatment of endocrine therapy–resistant breast cancer. Here, DNER is linked to breast carcinoma.