By integrating the RNA-Seq data from the MCF-7 Y537S cell lines with transcriptomic data of ER+ tumors from breast cancer patients harboring the same ESR1 mutation (11), we show that many of the top genes overexpressed in the mutant cell line are also overexpressed in patient samples and are targeted for inhibition by OTX015. This evidence concerns the gene ESR1 and breast carcinoma.