The induction of liver fibrosis by CCl4 led to a significant (P < 0.05) increase in the serum levels of alpha-2-macroglobulin and a significant (P < 0.05) decrease in APOA1 in serum after 5 and 9 weeks of CCl4 treatment compared to the control group. This evidence concerns the gene A2M and Hepatic fibrosis.