SLC5A2 and hydrops fetalis: The sister studies to EMPEROR-Preserved evaluating SGLT2 inhibition in HFrEF, the DAPA-HF and EMPEROR-Reduced trials, have similarly shown significant reductions in morbidity and mortality with SGLT2 inhibition (dapagliflozin and empagliflozin respectively), again independent of diabetic state [172–174].