In brief, uromodulin polymers in the urine protect against kidney stone formation and urinary tract infections (UTIs); uromodulin regulates sodium transport systems in the TAL and DCT, thus regulating blood pressure and urinary concentrating ability; it stabilizes TRPV5, TRPV6, and TRPM6 channels, thus increasing their activity in the DCT. This evidence concerns the gene UMOD and urinary tract infection.