Among the 1,526 differentially expressed genes identified, only 12 also significantly differed by stage (C1orf111, CCR4, POU5F1, CDCA7, CYP4A11, CD83, BTN2A2, PBXIP1, OSGEP, DYNLL1, CD1A, and PIM3), suggesting the expression differences identified between stage III and stage IV NSCLC tumors were not driven by EGFR-mutated tumors. This evidence concerns the gene BTN2A2 and non-small cell lung carcinoma.