There were also no significant differences between lesions with and without progression with respect to etiology of hepatitis B (p = 0.685), hepatitis C (p = 0.702) or alcoholic liver disease (p = 0.12), portal vein invasion (p = 0.288), Child-Pugh class (p > 0.99), BCLC stage (p = 0.296), extrahepatic metastasis (p = 0.534), alpha-fetoprotein (> 400 mg/dL, p = 0.434), diameter of index lesion (> 70 mm, p > 0.99), and presence of intralesional fat (p > 0.99). This evidence concerns the gene AFP and alcoholic liver diseases.