Consistent with our previous observation in mice (Fig. 5, E–G), these observations confirmed the on-target mechanism of sBCMA-Fc V3 on APRIL- and BAFF-mediated immunoglobulin production and class switching, confirming that the inhibition of APRIL/BAFF-mediated signaling can decreased immunoglobulin production in MM (Fig. 1 J). The gene discussed is TNFSF13B; the disease is Miyoshi myopathy.