EGFR and neoplasm: When the individual tumor types are summarized independently for targetable GAs, highlighted observations include a modest high-risk HPV incidence in penSCC when compared with crvSCC; higher frequencies of EGFR amplification in penSCC, murthSCC, and vulSC; higher rates of NOTCH pathway alterations in penSCC and vulSC; and the highest incidence of MTAP loss in the murthSCC cases.