NOTCH1 and squamous cell carcinoma of penis: However, data are still immature and conflicting leading to a lack of solid position in favor or against the use of NOTCH1-targeted therapies in medical oncology.45 Nevertheless, our analysis showed that the NOTCH1 pathway may be an important target in pSCC given is frequent activation and clinical trials of NOTCH inhibitors should thus be extended to patients with pSCC.