Cotransfection of the miR-217-5p mimic and GAS5-wt plasmid significantly reduced luciferase activity, whereas cotransfection of the miR-217-5p mimic and GAS5-mut did not alter luciferase activity (Figure 4B).PTEN, which can ameliorate lung fibrosis and inflammation, has been reported to be a primary target gene of miR-217-5p [17–19] . The gene discussed is GAS5; the disease is pulmonary fibrosis.