In patients with AML-M4 and AML-M2, the mRNA levels of NEDD8, UBE2M and RBX1 were higher than those in controls (P<0.001); however, there was no significant difference in the UBA3 mRNA expression (P>0.05, Figure 1E,F). This evidence concerns the gene NEDD8 and acute myeloid leukemia.