CDK2 and Familial prostate cancer: Trichostatin A (TSA), a classical histone deacetylase inhibitor, and genistein, a nontoxic dietary isoflavone isolated from Genista tinctoria, inhibited the expression of MCM2 and MCM2-7 loading factors, such as cyclin-dependent kinase 2 (CDK2), in prostate cancer [14].