Another example of dysfunctional Rab7‐mediated signaling in NDD is found in patients with Vici syndrome and recessive variants in the ectopic P‐granules autophagy protein 5 (EPG5) gene,28 where EPG5 deficiency causes a blockade in autophagosome‐lysosome tethering and deficient Rab7‐mediated signaling.29, 30. This evidence concerns the gene EPG5 and Neurodevelopmental delay.