Mitochondrial biogenesis is driven by PGC-1a (Goffart and Wiesner, 2003; Jornayvaz and Shulman, 2010), and PGC-1a dysregulation is seen in models of AKI development (Fontecha-Barriuso et al., 2020), with increased expression improving outcomes (Tran et al., 2011). This evidence concerns the gene PPARGC1A and acute kidney injury.