PPARGC1A and Sepsis: Glucose intolerance is a poor prognostic factor in sepsis (Bingham et al., 1980) and was noted as early as the 1970s (Bingham et al., 1980) to be associated with a state of hyperglucagonemia, reflecting a “metabolic energy deficit.” Hyperglucagonemia and high glucose cause inhibition of a number of intermediate cell pathways including sirtuins and PGC-1a (Vieira et al., 2013).