PPARGC1A and Sepsis: PGC-1a and the related mitochondrial regulator genes are prognostic factors for the outcomes after intensive care admission (Huang et al., 2021), and are heavily involved in mitochondrial fission-fusion homeostasis (Jornayvaz and Shulman, 2010), critical for the regulation of oxidative phosphorylation relevant for sepsis survival (Singer, 2017; Nedel et al., 2021).