Although there are several studies lending support to the use of [18F]AV-1451 for imaging tau in 4R tauopathies [10], [22], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], some others suggest that [18F]AV-1451 may not be the best fit for these circumstances [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]. Here, MAPT is linked to tauopathy.