Further, a significant drop in autoantibody titers between pemphigus diagnosis and the first 12 months of follow-up occurred in the vast majority of patients with PV (83.6% and 87.1% for anti-Dsg1 and anti-Dsg3, respectively) and PF (94.4% and 83.3% for anti-Dsg1 and anti-Dsg3, respectively). Here, DSG1 is linked to pemphigus.