In animal models, curcumin (0.36 mg/kg) has reduced blood pressure and urinary protein levels and improves renal injury in a rat model of lipopolysaccharide (LPS)-induced preeclampsia-like phenotype (LPS of 0.5 ug/kg), and further placental tissue analysis has revealed that curcumin improved trophoblastic invasion defects and spiral artery remodeling and decrease nuclear factor kappa B (NF-κB), IL-6, and monocyte chemoattractant protein 1 (MCP-1) mRNA expression in serum and placenta (16). This evidence concerns the gene CCL2 and preeclampsia.