Moreover, we observed that SIGLEC15, CD274, HAVCR2, PDCD1LG2, LAG3, PDCD1, CTLA4, and TIGIT were higher in ADCYAP1 and NPAS2-high CRC samples than in ADCYAP1 and NPAS2-low CRC samples (Figures 4(e) and 4(g)). This evidence concerns the gene LAG3 and colorectal carcinoma.