To begin with, we discovered that ARNTL2, CSNK1E, TIMELESS, BHLHE40, TIPIN, SERPINE1, NPAS2, SENP3, NR1D1, and GSK3B were highly upregulated, whereas VIP, PER3, CRY2, RORB, ARNTL, VIPR2, ADCYAP1, RORA, KLF10, and PER1 were significantly suppressed in both colon cancer and rectal cancer (Figure 1(a)). This evidence concerns the gene SERPINE1 and malignant colon neoplasm.