AHR and microcephaly: Giovannoni’s team found that ZIKV infection triggers aryl hydrocarbon receptor (AHR) activation by using genome-wide transcriptional studies and AHR inhibition with a nanoparticle-delivered AHR antagonist or an inhibitor developed for human use suppressed ZIKV replication and ameliorated newborn microcephaly in pregnant SJL mice through increasing IFN-I signaling (Giovannoni et al., 2020).