Microglia express high levels of PGRN (Mendsaikhan et al., 2019), and while studies have explored PGRN levels in brain tissue, those that studied PGRN in the context of T2D examined serum (Youn et al., 2009; Qu et al., 2013) and non-neuronal cell levels (Zhou et al., 2019b). Here, GRN is linked to type 2 diabetes mellitus.