In a previous study, the overexpression of GOLGA5 resulted in severe fragmentation of the Golgi ribbon [47, 48], and the overexpression of GM130 caused cell pathology in a model of lysosomal storage disease and cellular defects due to the absence or malfunctioning of lysosomal enzymes needed to break down glycosaminoglycans (GAGs) [50]. This evidence concerns the gene GOLGA5 and lysosomal storage disease.