IFNG and autoimmune disease: However, when analyses in that study were stratified by levels of cytokine expression of individual autoimmune diseases, those with overexpression of Interleukin-12 (IL-12) and interferon-gamma (IFN-γ) were associated, as a group, with lower risk of death, with similar trends among those diseases with underexpression of Interleukin-4 (IL-4) and Interleukin-10 (IL-10) [11].