As selective MAPKi were reported to promote T and NK cell infiltration into human metastatic melanoma [28, 29], it is feasible that IFN-γ- and TNF-producing T and NK cells can modulate TNFR2 expression by and induce MAPKi resistance in BRAFV600E+ metastatic melanomas. This evidence concerns the gene TNFRSF1B and metastatic melanoma.