However, while TNFR2 does not appear to mediate NF-κB signaling in response to solTNF, it does mediate p38 MAPK phosphorylation and plays a vitally supportive role for solTNF-mediated TNFR1 signaling and induction of MAPKi resistance in melanoma. The gene discussed is NFKB1; the disease is melanoma.