As shown in Fig. 3A, B PROS1 expression has a close relationship with the expression of 4 DNA methyltransferase genes (DNMT1, DNMT2, DNMT3A, and DNMT3B) and 44 RNA modifications (m1A [n = 10], m5C [n = 13], and m6A [n = 21]) across most human cancers, but especially in patients with LGG, which indicates that PROS1 may mediate tumorigenesis by epigenetic modification. This evidence concerns the gene TRDMT1 and cancer.