Taken together, PROS1 was upregulated in GBM, LGG, KIRC, KIRP, PAAD, PRAD, STAD, and THCA, and downregulated in BLCA, BRCA, CESC, CHOL, HNSC, KICH, LAML, LUAD, LUSC, OV, UCEC, and USC, demonstrating that PROS1 may function as a vital regulator of carcinogenesis in 20 different types of cancer. Here, PROS1 is linked to glioblastoma.