PROS1 and neoplasm: We additionally analysed PROS1 expression in 31 types of tissues using the GTEx dataset (Additional file 1: Fig. S1), determined its expression in 21 tumour cell lines using the Cancer Cell Line Encyclopedia database (Additional file 1: Fig. S2), and compared the expression between tumour and normal tissues using The Cancer Genome Atlas (TCGA) database (Additional file 1: Fig. S3).