STAT3 and osteosarcoma: Similarly, an in vitro study demonstrated that LIF was implicated in the high glucose (HG)-mediated inhibition of osteoblast differentiation in human osteosarcoma MG-63 cells by promoting STAT3/SOCS3 signalling, as the downregulation of osteogenic differentiation markers by LIF was restored by a STAT3 inhibitor [58] (Table 2; Fig. 3).