Using an animal model of heparin-induced osteoporosis, Walton et al. found that heparin enhanced both IL-11-induced STAT3-DNA complex formation and transactivation independent of tyrosine or serine phosphorylation of STAT3, leading to the expression of RANKL and gp130, which stimulated osteoclastogenesis and bone loss [93]. This evidence concerns the gene STAT3 and osteoporosis.