Although the role of naturally occurring autoantibodies to IgE and/or FcεRI in inflammatory disorders is still a fascinating and unsettled issue [109], several investigators have documented their presence in CSU [55, 61–64, 105–107, 110], asthma [57, 65, 111], and in AD patients [57–60, 67]. The gene discussed is IGHE; the disease is Alzheimer disease.