The Japanese consortium for ALS research (JaCALS) reported that the frequencies of SOD1, FUS/TLS, TARDBP, and VCP variants in Japanese FALS were 35.9%, 7.7%, 2.6%, and 2.6%, respectively (total of 39 FALS patients)4. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.