CXCL8 and neoplasm: CREB‐binding protein (CREBBP) was mutated more frequently in tumours with high stromal CXCL8 and when further analysis was performed on the TCGA/PanCancer Atlas dataset (n = 594) there was a significant association between CREBBP mutation and higher CXCL8 mRNA expression (p < 0.001) (Figure 4D).