Limitations of this study include a lack of mechanistic work and future experiments should include in vitro/in vivo experiments to determine the effect of CXCL8 ablation in fibroblasts cocultured with CRC cell lines/organoids and preliminary pathway inhibition to determine the therapeutic potential of drugs which target CXCL8/CXCR2 in right‐sided colon cancer models and in the metastatic setting. This evidence concerns the gene CXCL8 and malignant colon neoplasm.