SHH and medulloblastoma: Furthermore, there are 4 molecular groups: medulloblastoma, WNT-activated, medulloblastoma, SHH-activated (TP53-wildtype/mutant), medulloblastoma non-WNT/non-SHH (group 3) and medulloblastoma non-WNT/non-SHH (group 4), the two latter joint as medulloblastoma, non-WNT/non-SHH. Since both histopathological and molecular types have their well-defined clinicopathological characteristics, these features should be incorporated in an integrated diagnosis [27].