Hence, we aimed to fill this gap by assessing the effect that those factors have on caregiver burden, QoL, and emotional wellbeing in family caregivers of patients who belong to the largest worldwide cohort of EOAD due to the E280A mutation in presenilin 1 and patients with frontotemporal dementia (FTD) who are positive for other specific mutations. The gene discussed is PSEN1; the disease is frontotemporal dementia.