Mutations that constitutively activate members of the Ras family of oncogenes (H-Ras, N-Ras, and K-Ras) are collectively responsible for about one third of all human cancers; KRAS mutations in particular are implicated in the most fatal malignancies: pancreatic (91%), colon (42%) and lung (33%)1–4. The gene discussed is NRAS; the disease is cancer.