NRAS and cancer: Comparing IC50 values to gene mutation data from the Cancer Cell Line Encyclopedia (CCLE) revealed that the presence of at least one mutation in KRAS, HRAS, NRAS, and/or BRAF was significantly associated with lower IC50 values (P = 1.24 × 10−6), with median IC50 values of 65 nM in KRAS/HRAS/NRAS/BRAF-mutant cells versus 365 nM in cells with no mutations in these genes (Fig. 1e).