CDH17 and breast cancer: Bulk RNA sequencing (RNA-seq) of BC PDOs revealed differentially expressed genes (DEGs) between the six lowest versus the six highest TEG-sensitive PDO cultures (Supplementary Table 2), related to upregulated cadherin signaling and steroid biosynthesis pathways in TEG-insensitive cultures, whereas both cytokine signaling and extracellular matrix (ECM) organization, correlated with high sensitivity to TEG therapy (Fig. 1h and Extended Data Fig. 2a–c).