However, if patients have increased serum TG2-IgA titers and increased density of TCRγ/δ+ intraepithelial T cells7,8, with or without detectable submucosal IgA-TG2 immune complexes, they would be classified as having CD in which the degree of intestinal villous atrophy would depend on the amount of gluten consumed. This evidence concerns the gene CD79A and Cowden disease.