Also, our microarray findings suggest a gene signature indicative of cell-matrix remodeling, and previously others have reported upregulation of SPARC, which regulates cell adhesion27,56, and TEM7 (PLXDC1), which regulates cell spreading through an interaction with nidogen26,57 in TECs isolated from GBM tumors. This evidence concerns the gene PLXDC1 and glioblastoma.