Many of the genes we listed above, have been already associated with tumor vascularization propagation in other types of cancer—PECAM1, ESM1, CD146, CDH5, ENG, ICAM4, PTN, FGF1, ANKRD1, GATA2, KDR, NOS3, SERPINE1, TIE154,55. This evidence concerns the gene ESM1 and cancer.