Interestingly, genes upregulated in this category were included in subcategories revolving around cell movement, invasion of cells, and migration of endothelial cells, where particularly interesting were genes like SAA1, ENG, CDH5, PECAM1, DIO2, NOS3, MMP9 being responsible for tumor vascularization process (Fig. 4b). This evidence concerns the gene DIO2 and neoplasm.