These results also suggest that activity scores are comparable across kinases within an experiment, as the kinases with the highest activity scores in each tissue tended to be the ones you would expect, such as HCK and BTK in chronic myeloid leukemia cells and EGFR and ERBB2 in non-small cell lung carcinoma. Here, BTK is linked to chronic myelogenous leukemia, BCR-ABL1 positive.