ERBB2 and neoplasm: We considered three different cutoffs for making a binary decision of whether KSTAR predicts a tumor is “ERBB2 active”, based on FPR (less than 0.05 and 0.1) or by the activity score (greater than 3, or having less than 1 in a 1000 chance that the number of sites observed in ERBB2 networks occurred by random chance).