IFNAR1 and tongue neoplasm: We found blockade of IFNAR signaling—achieved with either pharmacological blockade or in ifnar−/− GEMM animals—in 4MOSC1-tongue tumor-bearing animals fail to respond to αCTLA-4, suggesting that IFNAR signaling is necessary for the host response to αCTLA-4 (Fig. 4j, k and Supplementary Fig. 4I).