Multiplex immunofluoresence analysis of tumor-draining lymph nodes (tdLNs) in 4MOSC1-tongue tumor-bearing animals reveals an accumulation of cDC1s (CD11c+CD8+CD103+CD3−) in αCTLA-4 treated animals compared to control-treated animals (Fig. 4b). The gene discussed is ITGAE; the disease is tongue neoplasm.