In prostate cancers, upregulated Snail suppressed the transcription of miR-128, a negative regulator of S6K1 mRNA, resulting in increased expression of S6K1, hypoxia-inducible factor 1 subunit alpha (HIF1α), and pyruvate kinase M 2 (PKM2) [77]. The gene discussed is RPS6KB1; the disease is Familial prostate cancer.