Of note, lncRNA PCA3 disrupted the binding of miR-106b with its target genes, including S6K1, in ovarian cancer cells; [83] lncRNA CCAT2 was responsible for radiotherapy resistance by downregulating miR-145-S6K1 in esophageal cancer cells [84] (Fig. 2). The gene discussed is RPS6KB1; the disease is esophageal cancer.