Our results showed that antiCAFs-DMS-AptT can significantly induce CD8+ T cell-mediated lysis on both CAFs and cancer cells (Supplementary Fig. 7a, b), indicating that antiCAFs-DMS-AptT indeed worked as a bispecific system to bridge CD8+ T cells to CAFs and exert cytotoxic effects on pancreatic cancer cells nearby. This evidence concerns the gene CD8A and pancreatic neoplasm.