The levels of F-K1057 and F-K1079 in WBCs of patients with T2D were not only higher than those of the non-T2D subjects but also positively correlated with HbA1c levels (Fig. 6e–h), consistent with F-K1057 and F-K1079 levels underlying insulin signaling inhibition and insulin resistance. This evidence concerns the gene INS and type 2 diabetes mellitus.