For instance, hnRNPA1 could recognize the specific DNA conformation of KRAS, a G4 structure, and form an EGF-KRAS-ILK-hnRNPA1 regulatory loop to maintain the invasive activity of pancreatic ductal adenocarcinoma (PDAC) cells [53, 54]. Here, HNRNPA1 is linked to pancreatic ductal adenocarcinoma.