First, we detected upregulation of multiple proinflammation cytokines in LC patients, such as TNF-α and IL-6 by antibody-based assay (Supplementary Fig. S2b), and macrophage colony-stimulating factor 1 (CSF1) by MS-based proteomics (Fig. 3g). The gene discussed is IL6; the disease is laryngotracheoesophageal cleft.