With high VEGFR1,2,3 expression, high PGF, VEGFA, VEGF-B and VEGF-D levels (and subsequently High MVD) and absence of pMET and pAXL NU12 can be seen as a classic sunitinib sensitive tumor, whereas SK-RC-52 tumors with no VEGFR3 expression, high VEGFC levels and the possibility to use redundant proliferation pathways are less dependent on the angiogenic component and represent a more sunitinib-resistant phenotype. Here, FLT4 is linked to neoplasm.