PGF and neoplasm: In contrast, our gene expression results differ from studies showing VEGF-A mRNA and PLGF upregulation in human oral SCC [59,84,104,105,106] and canine CSCC [86,87], although we report higher ratios of panVEGF-A relative to KDR in CSCC samples, suggestive of an abundance of ligand to receptor, thus favoring KDR activation within the tumor.