GPT and diabetes mellitus: In this study, the significant increase in the levels of liver function enzymes, ALT and AST; the significant reduction in serum albumin; and the increase in serum urea and creatinine, as well as the obvious damage in the structure of the hepatocytes and renal tubules, indicate that STZ-induced diabetes in rats is associated with hepatic and renal damage, which supports many other previous studies which utilized the same STZ-rat model [8,60,61].