Currently, accumulating data have shown that sustained hyperglycemia and oxidative stress exaggerate the hepatic and renal damage in diabetic animals by downregulating Nrf2 transcription and stimulating keap-1-induced degradation of Nrf2, a mechanism that leads to stimulating NF-κB and suppressing GSH and phase-II antioxidant enzyme [17]. This evidence concerns the gene KEAP1 and Hyperglycemia.