However, the obvious reduction in fasting hyperglycemia and the improvements in circulatory insulin levels and levels of HOMA-β in STZ + FS-AE and STZ + F-GAL-treated rats were our clearest evidence for the hypoglycemic effect of the FS-AE and F-GAL which are indicated to be a result of promoting the generation of pancreatic β-cells. This evidence concerns the gene INS and Hyperglycemia.