In polyp samples containing SEA-specific IgE antibodies, severe eosinophilic inflammation, manifested by the upregulation of IL-5, eosinophil chemokines, eosinophil cationic protein (ECP), and caspase-leukotriene synthesis, was observed, thus contributing to the severity of asthma [91]. This evidence concerns the gene RNASE3 and asthma.