PVL is an important virulence factor for the induction of apoptosis, acting on NLRP3 to induce macrophage death and IL-1β secretion during the course of pneumonia disease; PVL induces the release of the apoptotic proteins cytochrome c and Smac/DIABLO in mitochondria [62,65]. The gene discussed is IL1B; the disease is susceptibility to pneumonia measurement.