IFNG and chronic rhinosinusitis: In chronic sinusitis, insufficient IFN-γ-induced autophagy can lead to the p62-dependent apoptosis of epithelial cells, while TNF-α and IFN-γ-induced necroptosis may promote the production and release of numerous pro-inflammatory cytokines and lead to neutrophil infiltration to exacerbate inflammation in CRSwNP [293,294].